Figure 4From: siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cellsFunction and mRNA expression of P-glycoprotein after inhibitor treatment. (A) Doxorubicin efflux was measured after inhibitor treatment. Only C-4 (P-glycoprotein inhibitor) treatment inhibited doxorubicin efflux significantly. (Bcl-2 inh: Bcl-2 inhibitor) (B) mRNA expression of P-glycoprotein was measured by RT-PCR. All inhibitors did not change mRNA expression of P-glycoprotein. mRNA expression of P-glycoprotein of each inhibitor treatment was divided by mRNA expression of DMSO control. (Bcl-2 inh: Bcl-2 inhibitor).Back to article page