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Figure 7 | Molecular Cancer

Figure 7

From: siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells

Figure 7

Apoptosis after siRNA and doxorubicin treatment. (A) Microscopic pictures after siRNA and doxorubicin treatment are shown. Chondrosarcoma cells treated with siRNAs showed more apoptotic cells than control groups after doxorubicin treatment (NS: nonsilencing siRNA, PG: P-glycoprotein, original magnification ×100). (B) The effect of gene silencing on chemosensitivity in chondrosarcoma cells is shown. siRNA treatment enhanced chemosensitivity. siRNA treated chondrosarcoma cells demonstrated increased apoptosis after doxorubicin treatment in comparison to the control groups (up to 3.3 fold increase). Dual gene silencing (Bcl-xL+PG and XIAP +PG siRNA) also increased apoptosis significantly. (NS: nonsilencing siRNA, PG: P-glycoprotein, *: p < 0.05, +: p < 0.01, Nonsilencing siRNA treated group was used as a control for p-value.)

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