Skip to main content
Figure 9 | Molecular Cancer

Figure 9

From: siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells

Figure 9

Doxorubicin resistance mechanisms in chondrosarcoma cells. A schematic diagram demonstrates a molecular pathway of apoptosis that is triggered by doxorubicin. Doxorubicin damages DNA. This DNA damage induces cytochorome C release in mitochondria which activates caspases, the effectors of apoptosis. P-glycoprotein inhibits doxorubicin effect by drug efflux. Bcl-2 and Bcl-xL block cytochrome c release. XIAP inhibits caspase activation.

Back to article page

Molecular Cancer

ISSN: 1476-4598