Figure 1From: Senescence induction; a possible cancer therapyPrimary cells reach replicative senescence after several passages in culture. The passage number where they reach senescence is affected by the tissue conditions, etc. In addition, senescence can be forced to arise upon SIS. A senescence cell can remain arrested for a long period of time. Alternatively, epigenetic changes and/or stochastic mutation/s can lead it to escape from senescence.Back to article page