Figure 4
From: Corticotropin Releasing Factor promotes breast cancer cell motility and invasiveness
CRF enhances the invasion of MCF7 through ECM via CRF1. MCF7 cells were stimulated with 10-8 M CRF or vehicle (control) and the invasion assay was performed according to the manufacturer's instructions. CRF augmented the invasion of the cells through the ECM. Pretreatment with the CRF1 antagonist (10-6 M) abrogated the effect of CRF. Results represent the average of two independent experiments where each condition was assayed in triplicate. **p < 0.01 compared to untreated controls; #p < 0.05 compared to CRF-treated samples.