Figure 5
From: CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
Most significant gene networks for genes more methylated in papillary RCC than non-VHL sporadic cRCC. Genes in unfilled nodes were not identified as specifically methylated in tumours (AKT), were not represented on the array (SMAD3/SMAD4, RIL3, LRG1, TGFBR, FERMT1, P38MAPK, MYBPH, RNA polymerase II, insulin, PI3K, ERK, Ap1, SLC12A7, PDGFB, Pkc(s), CDO1, CNN2, VAPB, PDGFD) or were methylated in tumours but with no frequency difference between tumour types (CCNA1). The computationally generated networks were derived using the Ingenuity package http://www.ingenuity.com (see Figure 6 for key to nodal shape).