Identification of a gene signature changed by gemcitabine and Wee1 inhibitor combination in both p53 positive and negative paired cell lines. TOV21G positive and negative cell lines were treated with gemcitabine and Wee1 inhibitor as described in the legend of Figure 1, and mRNA from each treatment sample was applied to microarray analysis. A gene signature whose expression significantly changed in response to gemcitabine and Wee1 inhibitor treatment was extracted. Each row represents a sample from each treatment group. Each column represents a gene. Red, up-regulated genes; green, down-regulated genes.