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Table 1 Function of Wee1 inhibition gene signature

From: Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor

Gene

Function

CLSPN

Clspn triggers a checkpoint arrest of cell cycle by activating CHEK1 in response to DNA damage

FBXO5

Fbxo5 is a mitotic regulator interacting with CDC20 and inhibits the anaphase promoting complex

MCM10

Involved in S phase progression which interacts with chromatin during S phase and dissociates G2

CCNE1

CyclinE1 forms a complex with and functions as a regulatory subunit of CDK2

CCNE2

CyclinE2 forms a complex with and functions as a regulatory subunit of CDK2

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Molecular Cancer

ISSN: 1476-4598