Figure 7
From: Identification of novel Notch target genes in T cell leukaemia
IGLL1 is downregulated by Notch signalling in Jurkat cells. (A) Affymetrix data from Notch-transduced Jurkat cells. (B) cDNA from GFP-alone, N1ΔE, or N3ΔE-transduced Jurkat cells was used for PCR analysis of IGLL1 expression (using GFP-alone-treated cells as the calibrator). IGLL1 expression in response to GSI treatment was also analysed using DMSO (vehicle control)-treated cells as the calibrator. Expression of IGLL1 in DN-MAML-expressing cells was analysed using pMSCV (GFP-alone vector)-transduced cells as the calibrator. * represents p < 0.05 vesus the relevant calibrator sample.