Figure 5
From: Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo
HO-1 metabolites mediate resistance effects to chemotherapy. Cell growth was assessed 72 h after application of gemcitabine via MTT assay. (5A) Biliverdin administration biliverdin [5 and 50 μmol/l] resulted in increased proliferation of cancer cell line PANC-1 and S2-013, and therefore reduced the chemotherapeutic effect of gemcitabine (LD50 dose). (5B) Administration of ferrous histidinate revealed increased cell proliferation of PANC-1 and S2-013 cancer cells.