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Table 1 Tumors induced by co-expression of zebrafish smoa1 and constitutively active human AKT1

From: Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish

Tumor location (cases)

Fish age (weeks)

GFP expression

Elevated phospho-AKT1

Diagnoses

Trunk (4)

3

Yes

ND

Rhabdomyoma

 

4

Yes

Yes

ND

 

6

Yes

ND

ND

 

12

Yes

ND

Rhabdomyoma

Eye (3)

4

Yes

ND

Ocular Melanoma

 

12

Yes

Yes

Astrocytoma

 

12

Yes

ND

Astrocytoma

Head (4)

6

Yes

ND

Glioblastoma

 

6

Yes

ND

Glioblastoma

 

8

Yes

ND

ND

 

12

Yes

ND

Astrocytoma

Others (2)

4

Yes

ND

Myxoma

 

8

Yes

ND

Spindle cell sarcoma

  1. *The tumors were found from 4 batches of injection involving 147 injected F2 fish that had survived beyond 2-week-old. Fish were observed for one and a half years, no other tumors were found in fish more than 3 months of age. ND: Not determined.