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Table 2 Enhanced 13C enrichment of metabolites in lung cancer tissues relative to their non-cancerous counterpart

From: Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

Compound

% [U-13C]-AlaA

% [U-13C]-LactateA

% [U-13C]-GlucoseA

% [13C-2]-GluA

 

Non-cancerous

Cancer

Non-cancerous

Cancer

Non-cancerous

Cancer

Non-cancerous

Cancer

Mean

1.8

9.1

8.6

15.1

15.5

NDB

5.4

8.3

SDC

0.9

4.9

4.6

5.4

2.3

-

1.1

1.9

p valueD

0.009

0.02

-

0.012

  1. A Values are average of seven patients; % 13C-Ala, lactate, and Glu were determined from 2-D 1H TOCSY data using appropriate cross-peaks; % [U-13C]-glucose was obtained from 1-D 1H spectra.
  2. B Not detected or below detection limit; C Standard deviation; D from paired t-test