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Table 5 Changes in gene expression patterns of Krebs cycle and anaplerotic enzymes in lung tumor versus surrounding non-tumor tissues

From: Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

 

Fold ChangeA

GenesB

PC

GLS

IDH3

OGDH

SDH

FH

MDH2

AverageC

3.36

0.52

0.67

0.58

0.93

1.01

1.53

SD

1.13

0.16

0.13

0.09

0.19

0.23

0.29

p-valueD

0.03

0.04

0.05

0.01

0.24

0.31

0.04

  1. A Tumor over surrounding non-tumorous lung tissue
  2. B PC: pyruvate carboxylase; GLS: glutaminase; IDH: isocitrate dehydrogenase; OGDH: α-ketoglutarate dehydrogenase; FH: fumarate hydratase; MDH2: mitochondrial malate dehydrogenase
  3. C For patients #6–10
  4. D Obtained from paired t-test.
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Molecular Cancer

ISSN: 1476-4598