Figure 6
From: Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines
Proposed model of the relationship between p70S6K2 and the HH pathway. The activation of the canonical HH pathway is initiated by binding of the HH ligand to its receptor PTCH, which relieves the repression of SMOH. The activation of SMOH is translated into GLI zinc-finger transcription factors. Glycogen synthase kinase-3 beta (GSK3β) negatively regulates GLI transcription factors cooperating with other kinases such as PKA and CK1s. GSK3β is negatively regulated through phosphorylation by p70S6K2 which is a downstream effecter of the PI3K pathway.