Table 1 Kinase siRNAs suppressing GLI-mediated transcriptional activity
From: Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines
Kinases | Official Full Name | GLI Reporter Activity (%) |
|---|---|---|
ADCK5 | aarF domain containing kinase 5 | 27 ± 0.7 |
TNIK | TRAF2 and NCK interacting kinase | 31 ± 2.9 |
PIM3 | pim-3 oncogene | 34 ± 2.8 |
PAK6 | p21 protein (Cdc42/Rac)-activated kinase 6 | 35 ± 8.6 |
DCLK2 | doublecortin-like kinase 2 | 35 ± 1.7 |
ANKK1 | ankyrin repeat and kinase domain containing 1 | 35 ± 1.4 |
PCTK3 | PCTAIRE protein kinase 3 | 36 ± 4.8 |
PRKD2 | protein kinase D2 | 37 ± 5.3 |
p70S6K2 | ribosomal protein S6 kinase, polypeptide 2 | 38 ± 3.6 |
NLK | nemo-like kinasae | 39 ± 1.4 |
DKFZP434C131 | unc-51-like kinase 3 | 40 ± 3.6 |
MASTL | microtubule associated serine/threonine kinase-like | 42 ± 2.0 |
LATS2 | large tumor suppressor, homolog 2 | 42 ± 0.5 |
KSR2 | kinase suppressor of ras 2 | 43 ± 0.5 |
STK38L | serine/threonine kinase 38 like | 43 ± 2.8 |
MLK4 | mixed lineage kinase 4 | 44 ± 1.6 |
PRKCD | protein kinase C, delta | 45 ± 1.1 |