Figure 5
A single injection of GLV-1h68 results in complete regression of established MSKQLL2 flank tumors in vivo. A. Established MSKQLL2 flank tumors (n = 5 per group) were treated with a single intratumoral injection of GLV-1h68 (5 × 106 pfu) and followed. Measured tumor volumes for the GLV-1h68 group demonstrated nearly complete regression, with three out of five animals showing complete tumor resolution and the other two demonstrating only a tiny 1–2 mm remnant of skin thickening at the regressed tumor site. In contrast, there was significant progression of tumor volume for the control, PBS-treated group. There was no observed change in animal weight related to viral administration, and no evidence of any toxicity. B. A representative animal from each group was photographed at day 24.