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Table 3 Summary of EM findings from survey of 100 adherent NCI-H23 cells

From: Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells

  Cells with viral particles Multinucleated cells Nucleus
  + -   Condensed chromatin Normal
None 0 100 6 2 98
Paclitaxel 1 μM 0 100 22 11 (3*) 89
ReoT3D (MOI = 20) 37 63 3 4 (1*) 96
ReoT3D (MOI = 20) + Paclitaxel 1 μM 16 84 8 23 (17*) 77 (26§)
  1. Note: NCI-H23 cells surveyed represent adherent cells that remained after exposure to the listed agents, alone or in combination, thus excluding detached dead cells. *Number of apoptotic cells characterized by condensed/fragmented chromatin, cytoplasmic shrinkage and vacuolation. §Number of mitotic cells. Abbreviations: EM, electron microscopy; ReoT3D, reovirus type 3 Dearing; MOI, multiplicity of infection.