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Table 3 Summary of EM findings from survey of 100 adherent NCI-H23 cells

From: Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells

 

Cells with viral particles

Multinucleated cells

Nucleus

 

+

-

 

Condensed chromatin

Normal

None

0

100

6

2

98

Paclitaxel 1 μM

0

100

22

11 (3*)

89

ReoT3D (MOI = 20)

37

63

3

4 (1*)

96

ReoT3D (MOI = 20) + Paclitaxel 1 μM

16

84

8

23 (17*)

77 (26§)

  1. Note: NCI-H23 cells surveyed represent adherent cells that remained after exposure to the listed agents, alone or in combination, thus excluding detached dead cells. *Number of apoptotic cells characterized by condensed/fragmented chromatin, cytoplasmic shrinkage and vacuolation. §Number of mitotic cells. Abbreviations: EM, electron microscopy; ReoT3D, reovirus type 3 Dearing; MOI, multiplicity of infection.
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Molecular Cancer

ISSN: 1476-4598