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Figure 2 | Molecular Cancer

Figure 2

From: The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma

Figure 2

Cytogenetics and FISH results from the proposita's lymphocytes, A, cut-out and B, idiogram of the normal (left) and derivative (right) chromosomes 8 and 22. C, FISH with BAC RP11-562F10 (red signals) spanning the breakpoint on the long arm of chromosome 22. D, FISH with BAC RP11-158K1 demonstrates that the chromosome 8 breakpoint is within this clone. Arrowheads indicate the signal on the normal chromosome while arrows mark derivative chromosomes.

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