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Figure 4 | Molecular Cancer

Figure 4

From: The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma

Figure 4

Interphase FISH on deparaffinized sections from dysgerminoma. a) schematic representation of the results of the interphase FISH. b) Nuclei show two or three red signals (CEP8) indicating the presence of nuclei with two or three chromosomes 8, respectively.c) Dual color hybridization with BAC RP11-383J24 (red signal) and BAC CTD-2319K10 (green signal) indicate the presence of a normal chromosome 8 and a normal chromosome 22 (single signals); nuclei show one or two derivative chromosome 8 (arrows). d) Dual color hybridization with BAC CTD-3107D22 (red signal) and BAC RP11-532M24 (green signal) indicate the presence of a normal chromosome 8 and a normal chromosome 22 (single signals) and one or two derivative chromosome 22 (arrows).

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