The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma

Table 2 Genomic typing of somatic cell hybrid clones with chromosome 8 and 22 markers.

	Locus	Position (Kb)	Genomic	Chr. 8	Chr. 22	der(8)	der(22)
Chromosome 8	D8S1784	106172	287	287		287
	D8S514	123811	221/223	223		221
	D8S1832	125517	180/186	180		186
	RH1927	125534	+	+		+
	RNF139 E1	125556	+	+		+
	Chr8-2-1	125559	+	+		+
	Chr8-2-2	125562	+	+		+
	Chr8-3-1	125563	+	+		+
	Chr8-3-2	125564	+	+			+
	Chr8-2-3	125565	+	+			+
	RNF139 E2	125567	+	+			+
	TATDN1 E10	125570	+	+			+
	TATDN1 E6	125590	+	+			+
	NDUFB9 E2	125625	+	+			+
	NDUFB9 E4	125631	+	+			+
	MTSS1 E14	125635	+	+			+
	MTSS1 E13	125637	+	+			+
	MTSS1 E11	125639	+	+			+
	D8S1799	125646	234	234			234
	D8S272	137804	241/255	255			241
Chromosome 22	D22S427	16971	100		100		100
	RH78249	18480	+		+		+
	RH57884	18609	+		+		+
	RH102235	19092	+		+	+
	RH93744	19126	+		+	+
	D22S280	31539	210/212		210	212

ISSN: 1476-4598