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Figure 3 | Molecular Cancer

Figure 3

From: 14-3-3σ gene silencing during melanoma progression and its role in cell cycle control and cellular senescence

Figure 3

Treatment of melanoma cells with 5-Aza-CdR, Pba, and 5-Aza-CdR/Pba, respectively, induces 14-3-3σ expression and leads to inhibition of cell cycle progression. (a) 14-3-3σ immunoblot analyses of melanoma cell lines SK-Mel-19, SK-Mel-29 and SK-Mel-147, treated with 5-Aza-CdR (3 μM), Pba (3 mM), and a combination of both, respectively, for indicated times points or left untreated. (b) Cell cycle analysis of melanoma cell line SK-Mel-147 by flow cytometry after treatment as described in (a). Data are given as mean values +/- SD of four independent experiments.

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