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Figure 5 | Molecular Cancer

Figure 5

From: 14-3-3σ gene silencing during melanoma progression and its role in cell cycle control and cellular senescence

Figure 5

14-3-3σ induces cellular senescence in melanoma cells. (a) Expression of senescence marker SA-β-Gal in untransduced, vector control or 14-3-3σ cDNA transduced SK-Mel-147 melanoma cells. (b) SK-Mel-19 melanoma cells were exposed to 3.0 μg/ml adriamycin for indicated time points to induce cellular senescence. Induction of p53, 14-3-3σ and SA-β-Gal was analyzed by immunoblotting or immunohistochemistry in untransduced, vector control or 14-3-3σ shRNA (si14-3-3B4) transduced cells.

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