Figure 4

Enhanced calcium release from the endoplasmic reticulum in EBV-infected cells. Calcium mobilisation from the thapsigargin-sensitive endoplasmic reticulum calcium pool in non-infected (black curves), and EBV-infected cells (grey curves) was measured in BL-30 (Panels A and C) and BL-41 (Panels B and D) cells. Thapsigargin-induced calcium release from the cells was recorded in the absence (Panels A and B), and in the presence (Panels C and D) of inhibition of PMCA and Na⁺/Ca²⁺ exchanger-dependent calcium extrusion across the plasma membrane. Panels E and F: Area under curve values of the plateau phase of calcium release obtained in Panels C and D expressed in arbitrary units (AUC). Black columns: non-infected, grey columns: infected cells.