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Table 2 Univariate statistics Astro vs MB vs NB. Mean and standard error (SE) of metabolite levels for astrocytoma G1 (Astro) (N = 10), medulloblastoma (MB) (N = 9) and neuroblastoma (NB) (N = 7) tissue.

From: High resolution magic angle spinning 1H NMR of childhood brain and nervous system tumours

Metabolite

Astro

MB

NB

Two-tailed t-test (MB vs NB)

 

Mean

SE

Mean

SE

Mean

SE

P value

NAA

0.90

0.29

0.66

0.22

1.26

0.48

-

Ace

0.19

0.06

0.09

0.03

0.17

0.06

-

Ala

1.63

0.51

1.48

0.49

1.25

0.47

-

Asp

0.54

0.17

0.22

0.07

0.32

0.12

-

Cho

0.52

0.17

0.68

0.23

0.81

0.30

-

Cr

2.45

0.77

2.05

0.68

0.96

0.36

< 0.01

Glu

2.57

0.81

2.90

0.97

3.50

1.32

-

Gln

5.36

1.69

3.15

1.05

0.61

0.23

< 0.001

GPC

0.81

0.25

0.60

0.20

0.61

0.23

-

Gly

1.57

0.50

2.83

0.94

1.29

0.49

< 0.05

Lac

13.5

4.27

9.29

3.10

11.2

4.24

-

m-Ins

2.25

0.71

1.72

0.57

2.72

1.03

-

PC

0.66

0.21

2.45

0.82

0.87

0.33

< 0.05

PEth

1.19

0.38

2.67

0.89

1.61

0.61

-

s-Ins

0.35

0.11

0.42

0.14

0.23

0.09

< 0.05

Suc

0.09

0.03

0.07

0.02

0.09

0.03

-

Tau

0.90

0.28

2.61

0.87

1.92

0.73

-

  1. Statistically significant differences between medulloblastomas and neuroblastomas resulting from two-tailed students t-tests assuming unequal variances are indicated. All metabolite quantities were divided by the fitted spectral area between 0.5 and 4.5 ppm. Tau – Taurine, Suc – Succinate, s-Ins – scyllo inositol, PEth – phosphorylethanolamine, PC – phosphorylcholine, m-Ins – myo-inositol, Lac – lactate, Gly – glycine, GPC – glycerophosphorylcholine, Gln – glutamine, Glu – glutamate, Cr – creatine, Cho – choline, Asp – aspartate, Ala – alanine, Ace – aspartate, NAA – N-acetylaspartate.