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Table 1 Distribution of the genotypes of the three CDH1 promoter polymorphisms in gastric cancer patients

From: Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients

Genetic polymorphisma dbSNP IDb Samplesc Number of patients with a heterozygous genotype (%) Number of patients homozygous for a varinat allele (%) Variant allele frequency
-348_-347insA rs5030625 F/EGC 9 (23.1%) 4 (10.3%) 21.8%
   SGC 55 (34.6%) 15 (9.4%) 26.7%
-161C>A rs16260 F/EGC 11 (28.2%) 0 (0.0%) 14.1%
   SGC 51 (32.1%) 7 (4.4%) 20.4%
-73A>C rs28372783 F/EGC 5 (12.8%) 0 (0.0%) 6.4%
   SGC 19 (11.9%) 0 (0.0%) 6.0%
  1. a Nucleotide +1 is the transcription start site. The reference sequence is accession number NT_010498.
  2. b Identification number registered in the database of single nucleotide polymorphisms (dbSNP) homepage of the National Center for Biotechnology Information web site http://www.ncbi.nlm.nih.gov/SNP/.
  3. c F/EGC, familial gastric cancer or early-onset gastric cancer; SGC, sporadic gastric cancer.