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Table 1 Distribution of the genotypes of the three CDH1 promoter polymorphisms in gastric cancer patients

From: Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients

Genetic polymorphisma

dbSNP IDb

Samplesc

Number of patients with a heterozygous genotype (%)

Number of patients homozygous for a varinat allele (%)

Variant allele frequency

-348_-347insA

rs5030625

F/EGC

9 (23.1%)

4 (10.3%)

21.8%

  

SGC

55 (34.6%)

15 (9.4%)

26.7%

-161C>A

rs16260

F/EGC

11 (28.2%)

0 (0.0%)

14.1%

  

SGC

51 (32.1%)

7 (4.4%)

20.4%

-73A>C

rs28372783

F/EGC

5 (12.8%)

0 (0.0%)

6.4%

  

SGC

19 (11.9%)

0 (0.0%)

6.0%

  1. a Nucleotide +1 is the transcription start site. The reference sequence is accession number NT_010498.
  2. b Identification number registered in the database of single nucleotide polymorphisms (dbSNP) homepage of the National Center for Biotechnology Information web site http://www.ncbi.nlm.nih.gov/SNP/.
  3. c F/EGC, familial gastric cancer or early-onset gastric cancer; SGC, sporadic gastric cancer.
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Molecular Cancer

ISSN: 1476-4598