Figure 7From: Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagyEffect of celecoxib on DNA damage and DNA synthesis. U87MG cells were treated with celecoxib (8 and 30 μM) and analysed for DNA damage by Comet assays, as shown by representative images and quantitated as comet tail moments (A, n = 5–7). DNA synthesis is presented by incorporation of [3H]-thymidine/[14C]-thymidine in celecoxib-treated cells normalised over controls (B, n = 3–4). *P < 0.05, significantly different from respective controls (1-way ANOVA, Dunnett's test).Back to article page