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Table 4 Top pathways

From: Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers

  Pathway Size % up Change q-value
HIF Hypoxia-Inducible Factor in the Cardiovascular System 31 65 up 0
PROTEASOME Proteasome Complex 37 89 up 5.00E-04
MYOSIN PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase 25 28 down 0.00367
VITCB Vitamin C in the Brain 28 61 up 0.0055
LYMPHOCYTE Adhesion Molecules on Lymphocyte 27 81 up 0.00942
NOS1 Nitric Oxide Signaling 53 25 down 0.00942
P53HYPOXIA Hypoxia and p53 in the Cardiovascular system 36 72 up 0.00942
SALMONELLA How does salmonella hijack a cell 26 81 up 0.00942
ATM ATM Signaling 36 72 up 0.00942
CASPASE Caspase Cascade in Apoptosis 43 72 up 0.00942
PAR1 Thrombin signaling and protease-activated receptors 39 31 down 0.00942
G2 Cell Cycle: G2/M Checkpoint 43 70 up 0.00942
TSP1 TSP-1 Induced Apoptosis in Microvascular Endothelial Cell 21 86 up 0.00946
ACTINY Y branching of actin filaments 31 77 up 0.0109
NEUTROPHIL Neutrophil and Its Surface Molecules 21 81 up 0.0152
ATRBRCA Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility 40 85 up 0.0152
MONOCYTE Monocyte and its Surface Molecules 30 80 up 0.0155
FAS FAS signaling (CD95) 65 62 up 0.0177
PGC1A Regulation of PGC-1a 54 24 down 0.0184
CELLCYCLE Cyclins and Cell Cycle Regulation 37 73 up 0.0186
VEGF VEGF, Hypoxia, and Angiogenesis 54 61 up 0.0186
  1. Pathways with overall q-value < 2%. Columns are the full Biocarta pathway name, the number of genes in the pathway, the percentage of genes that are expressed more highly in GBM relative to AA, the direction of change of the pathway in GBM vs. AA, and the q-value.