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Table 4 Top pathways

From: Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers

 

Pathway

Size

% up

Change

q-value

HIF

Hypoxia-Inducible Factor in the Cardiovascular System

31

65

up

0

PROTEASOME

Proteasome Complex

37

89

up

5.00E-04

MYOSIN

PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase

25

28

down

0.00367

VITCB

Vitamin C in the Brain

28

61

up

0.0055

LYMPHOCYTE

Adhesion Molecules on Lymphocyte

27

81

up

0.00942

NOS1

Nitric Oxide Signaling

53

25

down

0.00942

P53HYPOXIA

Hypoxia and p53 in the Cardiovascular system

36

72

up

0.00942

SALMONELLA

How does salmonella hijack a cell

26

81

up

0.00942

ATM

ATM Signaling

36

72

up

0.00942

CASPASE

Caspase Cascade in Apoptosis

43

72

up

0.00942

PAR1

Thrombin signaling and protease-activated receptors

39

31

down

0.00942

G2

Cell Cycle: G2/M Checkpoint

43

70

up

0.00942

TSP1

TSP-1 Induced Apoptosis in Microvascular Endothelial Cell

21

86

up

0.00946

ACTINY

Y branching of actin filaments

31

77

up

0.0109

NEUTROPHIL

Neutrophil and Its Surface Molecules

21

81

up

0.0152

ATRBRCA

Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility

40

85

up

0.0152

MONOCYTE

Monocyte and its Surface Molecules

30

80

up

0.0155

FAS

FAS signaling (CD95)

65

62

up

0.0177

PGC1A

Regulation of PGC-1a

54

24

down

0.0184

CELLCYCLE

Cyclins and Cell Cycle Regulation

37

73

up

0.0186

VEGF

VEGF, Hypoxia, and Angiogenesis

54

61

up

0.0186

  1. Pathways with overall q-value < 2%. Columns are the full Biocarta pathway name, the number of genes in the pathway, the percentage of genes that are expressed more highly in GBM relative to AA, the direction of change of the pathway in GBM vs. AA, and the q-value.