Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times

Table 4 Gene transcripts overexpressed in short survivors of canine OS found associated with 3 main biological processes

Gene ID	Fold change	Gene description	Gene symbol
Metastasis-associated
DG2-23c15	3.3	cofilin 2	CFL2
DG14-14i19	1.7	Stress-70 protein, mitochondrial precursor (HSAP9) (GRP 75) (Mortalin)	MOT
DG2-72p3	1.6	Vacuolar ATP synthase subunit C	V-ATPase C
Drug resistance
DG2-112n11	2.1	Kinesin heavy chain (Ubiquitous kinesin heavy chain)	UKHC
DG2-123a3	2.0	Microsomal glutathione S-transferase 1	MGST1
DG2-72p3	1.6	Vacuolar ATP synthase subunit C	V-ATPase C
DG2-94j4	1.5	high-mobility group box 1	HMGB1
Cell cycle/proliferation
DG2-23c15	3.3	cofilin 2	CFL2
DG32-161c11	2.0	WNK lysine deficient protein kinase 1	WNK1
DG14-71c7	1.8	serine/arginine repetitive matrix 1	SRRM1
DG14-14i19	1.7	Stress-70 protein, mitochondrial precursor (HSAP9) (GRP 75) (Mortalin)	MOT
DG32-237k11	1.6	Ribosomal L1 domain containing protein 1(PBK1 protein)	RSL1D1
DG11-239n21	1.6	cell-cycle and apoptosis regulatory protein 1	CCAR1
DG2-106f2	1.4	Translocation protein SEC63 homolog	SEC63
DG2-25k5	1.4	SMC6 protein	SMC6

The 3 processes commonly confer for the aggressive phenotype of tumor in general which include increased drug resistance, high proliferation and differentiation and high metastasis.