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Table 4 Gene transcripts overexpressed in short survivors of canine OS found associated with 3 main biological processes

From: Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times

Gene ID Fold change Gene description Gene symbol
Metastasis-associated
DG2-23c15 3.3 cofilin 2 CFL2
DG14-14i19 1.7 Stress-70 protein, mitochondrial precursor (HSAP9) (GRP 75) (Mortalin) MOT
DG2-72p3 1.6 Vacuolar ATP synthase subunit C V-ATPase C
Drug resistance
DG2-112n11 2.1 Kinesin heavy chain (Ubiquitous kinesin heavy chain) UKHC
DG2-123a3 2.0 Microsomal glutathione S-transferase 1 MGST1
DG2-72p3 1.6 Vacuolar ATP synthase subunit C V-ATPase C
DG2-94j4 1.5 high-mobility group box 1 HMGB1
Cell cycle/proliferation
DG2-23c15 3.3 cofilin 2 CFL2
DG32-161c11 2.0 WNK lysine deficient protein kinase 1 WNK1
DG14-71c7 1.8 serine/arginine repetitive matrix 1 SRRM1
DG14-14i19 1.7 Stress-70 protein, mitochondrial precursor (HSAP9) (GRP 75) (Mortalin) MOT
DG32-237k11 1.6 Ribosomal L1 domain containing protein 1(PBK1 protein) RSL1D1
DG11-239n21 1.6 cell-cycle and apoptosis regulatory protein 1 CCAR1
DG2-106f2 1.4 Translocation protein SEC63 homolog SEC63
DG2-25k5 1.4 SMC6 protein SMC6
  1. The 3 processes commonly confer for the aggressive phenotype of tumor in general which include increased drug resistance, high proliferation and differentiation and high metastasis.
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Molecular Cancer

ISSN: 1476-4598