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Table 1 Correlation between Leptin-R(Ob-R) Status and clinical status in Epithelial Ovarian Carcinoma (EOC).

From: Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer

Epithelial Group    Leptin-R high Leptin-R low P value
  N % N % N %  
Total Number of Cases 152   90 59.2 62 40.8  
Age        
   < = 50 years 59 38.8 34 57.6 25 42.4 0.7519
   >50 years 93 61.2 56 60.2 37 39.8  
Tumour Stage        
   Stage I-II 8 5.6 5 62.5 3 37.5 0.8749
   Stage III-IV 134 94.4 80 59.7 54 40.3  
Histopathology        
   Clear cell 4 2.6 3 75.0 1 25.0 0.2909
   Endometriod 21 13.8 13 61.9 8 38.1  
   Serous 122 80.3 73 59.8 49 40.2  
   Undifferentiated 5 3.3 1 20.0 4 80.0  
FIGO Grade        
   Well differentiated 27 17.8 15 55.6 12 44.4 0.9031
   Moderately Diff 81 53.3 49 60.5 32 39.5  
   Poorly Diff 44 29.0 26 59.1 18 40.9  
P-AKT Ser 473        
   High (2-3) 75 52.1 49 65.3 26 34.7 0.2082
   Low (0-1) 69 47.9 38 55.1 31 44.9  
pGSK3B(Ser9)        
   Above 45 116 81.7 77 66.4 39 33.6 0.0009
   Below = 45 26 18.3 8 30.8 18 69.2  
PTEN        
   0-1 33 22.9 11 33.3 22 66.7 0.0002
   2-3 111 77.1 77 69.4 34 30.6  
XIAP        
   Above 70 128 88.3 84 65.6 44 34.4 0.0001
   Below = 70 17 11.7 3 17.6 14 82.4  
Bcl-XL        
   Above 180 122 85.9 79 64.7 43 35.3 0.0035
   Below = 180 20 14.1 6 30.0 14 70.0  
PFS Median (Months)^    13.1   21.0   0.0032
  1. #of the 152 EOCs with available Ob-R expression data, FIGO stage was available only in 142 cases; in remaining stage was unknown.
  2. $ Analysis failure of some markers for these IHC markers was attributed to missing or non representative spots
  3. ^PFS= progression free survival