Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer

Table 1 Correlation between Leptin-R(Ob-R) Status and clinical status in Epithelial Ovarian Carcinoma (EOC).

Epithelial Group			Leptin-R high		Leptin-R low		P value
	N	%	N	%	N	%
Total Number of Cases	152		90	59.2	62	40.8
Age
< = 50 years	59	38.8	34	57.6	25	42.4	0.7519
>50 years	93	61.2	56	60.2	37	39.8
Tumour Stage
Stage I-II	8	5.6	5	62.5	3	37.5	0.8749
Stage III-IV	134	94.4	80	59.7	54	40.3
Histopathology
Clear cell	4	2.6	3	75.0	1	25.0	0.2909
Endometriod	21	13.8	13	61.9	8	38.1
Serous	122	80.3	73	59.8	49	40.2
Undifferentiated	5	3.3	1	20.0	4	80.0
FIGO Grade
Well differentiated	27	17.8	15	55.6	12	44.4	0.9031
Moderately Diff	81	53.3	49	60.5	32	39.5
Poorly Diff	44	29.0	26	59.1	18	40.9
P-AKT Ser 473
High (2-3)	75	52.1	49	65.3	26	34.7	0.2082
Low (0-1)	69	47.9	38	55.1	31	44.9
pGSK3B(Ser9)
Above 45	116	81.7	77	66.4	39	33.6	0.0009
Below = 45	26	18.3	8	30.8	18	69.2
PTEN
0-1	33	22.9	11	33.3	22	66.7	0.0002
2-3	111	77.1	77	69.4	34	30.6
XIAP
Above 70	128	88.3	84	65.6	44	34.4	0.0001
Below = 70	17	11.7	3	17.6	14	82.4
Bcl-XL
Above 180	122	85.9	79	64.7	43	35.3	0.0035
Below = 180	20	14.1	6	30.0	14	70.0
PFS Median (Months)^			13.1		21.0		0.0032

#of the 152 EOCs with available Ob-R expression data, FIGO stage was available only in 142 cases; in remaining stage was unknown.
$ Analysis failure of some markers for these IHC markers was attributed to missing or non representative spots
^PFS= progression free survival

ISSN: 1476-4598