Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer

Table 3 Correlation between leptin Status and clinical status in Epithelial Ovarian Carcinoma (EOC).

Epithelial Group			Leptin High		Leptin low		p value
	N	%	N	%	N	%
Total Number of Cases	143		128	89.5	15	10.5
Age
< = 50 years	57	39.9	53	93.0	4	7.0	0.2588
>50 years	86	60.1	75	87.2	11	12.8
Tumour Stage
Stage I-II	8	6.0	7	87.5	1	12.5	0.9115
Stage III-IV	125	94.0	111	88.8	14	11.2
Histopathology
Clear cell	4	2.8	3	75.0	1	25.0	0.6630
Endometriod	21	14.7	19	90.5	2	9.5
Serous	114	79.7	102	89.5	12	10.5
Undifferentiated	4	2.8	4	100.0	0	0
FIGO Grade
Well differentiated	27	18.9	24	88.9	3	11.1	0.9815
Moderately Diff	75	52.5	67	89.3	8	10.7
Poorly Diff	41	28.7	37	90.2	4	9.8
P-AKT Ser 473
High (2-3)	74	52.1	70	94.6	4	5.4	0.0344
Low (0-1)	68	47.9	57	83.8	11	16.2
pGSK3B(Ser9)
Above 45	116	81.7	103	88.8	13	11.2	0.5852
Below = 45	26	18.3	24	92.3	2	7.7
PTEN
Low (0-1)	32	22.5	27	84.4	5	15.6	0.3096
High (2-3)	110	77.5	100	90.9	10	9.1
XIAP
Above 70	124	87.9	112	90.3	12	9.7	0.3500
Below = 70	17	12.1	14	82.3	3	17.7
Bcl-XL
Above 180	122	85.9	111	91.0	11	9.0	0.1724
Below = 180	20	14.1	16	80.0	4	20.0
PFS Median (Months)^				17.0		10.3	0.1422

# of the 143 EOCs with available Ob-R expression data, FIGO stage was available only in 133 cases; in remaining stage was unknown.
$ Analysis failure of some markers for these IHC markers was attributed to missing or non representative spots
^PFS= progression free survival

ISSN: 1476-4598