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Table 3 Correlation between leptin Status and clinical status in Epithelial Ovarian Carcinoma (EOC).

From: Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer

Epithelial Group    Leptin High Leptin low p value
  N % N % N %  
Total Number of Cases 143   128 89.5 15 10.5  
Age        
   < = 50 years 57 39.9 53 93.0 4 7.0 0.2588
   >50 years 86 60.1 75 87.2 11 12.8  
Tumour Stage        
   Stage I-II 8 6.0 7 87.5 1 12.5 0.9115
   Stage III-IV 125 94.0 111 88.8 14 11.2  
Histopathology        
   Clear cell 4 2.8 3 75.0 1 25.0 0.6630
   Endometriod 21 14.7 19 90.5 2 9.5  
   Serous 114 79.7 102 89.5 12 10.5  
   Undifferentiated 4 2.8 4 100.0 0 0  
FIGO Grade        
   Well differentiated 27 18.9 24 88.9 3 11.1 0.9815
   Moderately Diff 75 52.5 67 89.3 8 10.7  
   Poorly Diff 41 28.7 37 90.2 4 9.8  
P-AKT Ser 473        
   High (2-3) 74 52.1 70 94.6 4 5.4 0.0344
   Low (0-1) 68 47.9 57 83.8 11 16.2  
pGSK3B(Ser9)        
   Above 45 116 81.7 103 88.8 13 11.2 0.5852
   Below = 45 26 18.3 24 92.3 2 7.7  
PTEN        
   Low (0-1) 32 22.5 27 84.4 5 15.6 0.3096
   High (2-3) 110 77.5 100 90.9 10 9.1  
XIAP        
   Above 70 124 87.9 112 90.3 12 9.7 0.3500
   Below = 70 17 12.1 14 82.3 3 17.7  
Bcl-XL        
   Above 180 122 85.9 111 91.0 11 9.0 0.1724
   Below = 180 20 14.1 16 80.0 4 20.0  
PFS Median (Months)^     17.0   10.3 0.1422
  1. # of the 143 EOCs with available Ob-R expression data, FIGO stage was available only in 133 cases; in remaining stage was unknown.
  2. $ Analysis failure of some markers for these IHC markers was attributed to missing or non representative spots
  3. ^PFS= progression free survival
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Molecular Cancer

ISSN: 1476-4598