Table 1 Centrosome-associated G2/M checkpoint proteins

cyclin B/Cdk1 [33]

Drp1/Dnml1, HuR, hnRNP-k, TPX2

mitosis entry, bipolar spindle assembly

inhibition: induce cell cycle arrest and apoptosis

Aurora A[34, 35, 76]

centrosomin, γ-TuRC, Eg5, Ran-TPX2, CENP-A, PP1, p53, Cdh1, NM23-H1, CPEB, Cdc25B, TPX2

mitotic entry and exit, centrosome mutation and separation, spindle formation

inhibition: monopolar spindle overexpression: centrosome amplification and loss of mitotic checkpoint

Aurora B[34, 35]

INCEP, Survivin, BubR1, Mad2

chromatid separation, spindle assembly checkpoint

inhibition: multinucleate cells

Plk1[21, 34, 36]

Cdc25, cyclinB/Cdk1, p53, Nlp1, ATM/ATR, BRCA1, Chk1, Emi1, Wee1

mitotic entry and exit, APC/C regulation, bipolar spindle formation, centrosome maturation,

inhibition: smaller centrosomes

Nek2A[18, 34, 101]

PP1, C-Nap1

centrosome separation and maturation, mitotic entry

overexpression: split centrosomes

Survivin[90, 91, 102]

Caspases 3, 7, 9, Aurora B, INCENP

anti-apoptosis

inhibition: loss of mitotic kinases and checkpoint, supernumerary centrosome

p53[47, 48]

p21, 14-3-3, GADD45

centrosome duplication

inhibition: centrosome amplication

BRCA1[51, 52]

γ-Tubulin, Chk1/2, p53, Cdc25, Wee1, Aurora A

centrosome duplication

inhibition: centrosome re-duplication and hyperactive MT nucleation

APC/C[99]

Cyclin B/Cdk1, securin, Aurora A, Plk1, Cdk2

sister chromatid separation, mitotic exit, proteasomal degradation

NA

ATM/ATR[55]

p53, Chk1/2, BRCA1, Mdm2

initiation of genotoxic stress response

NA

Chk1/2 [56–59]

Cdc25, BRCA1, E2F, p73α

centrosome separation, mitotic entry

inhibition: centrosome amplification and mitotic arrest