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Figure 5 | Molecular Cancer

Figure 5

From: Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells

Figure 5

Influence of doxorubicin on viability of neuroblastoma cells, growth of doxorubicin-resistant neuroblastoma xenografts, and vessel formation in doxorubicin-resistant neuroblastoma xenografts. A) Dose-response curves of parental chemosensitive neuroblastoma cell cultures (UKF-NB-3; black square) or the doxorubicin-resistant sub-line (UKF-NB-3rDOX20; black dot) after 24 h or 120 h incubation periods. B) Tumour volumes in mice injected with 107 UKF-NB-3rDOX20 cells; doxorubicin treatment (8 mg/kg i.v.) was performed at day 1, i.e. when tumours became palpable. C) Representative photographs of angiogenesis in untreated or doxorubicin-treated UKF-NB-3rDOX20 xenograft tumours by red (anti-CD31 antibody-stained) vessels at day 16. D) Microvessel density in untreated or doxorubicin-treated UKF-NB-3rDOX20 xenografts at day 16. * P < 0.05 relative to UKF-NB-3 tumours.

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Molecular Cancer

ISSN: 1476-4598