Figure 2

GILZ expression correlates with p-AKT levels and with cell proliferation in epithelial ovarian cancer (EOC). (A) Serial sections of tumors with staining for p-AKT, GILZ and Ki-67. Negative control was done without primary Ab. Original magnifications, ×20 and ×63. Pictures show cytoplasmic staining for GILZ and nuclear staining for Ki-67; p-AKT staining is mostly in the cytoplasm with some additional nuclear staining (arrow). (B) GILZ and Ki-67 final scores were positively correlated (Spearman test in univariate analysis, P < 0.00001, r = 0.56). (C) GILZ scores for p-AKT^high and p-AKT^low groups (the difference was significant at P < 0.05, Student's t test). Insets: high and low p-AKT immunoreactivity is shown on representative micrographs.