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Table 1 Effects of Aza and TSA on TSG expression in MLL wt AML cell lines.

From: Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in Acute Myeloid Leukemia

cell line treatment TSG
   BEX2 IGSF4 TIMP3
AML-193 TSA - - +
  Aza ++ ++ +++
  Aza + TSA ++ ++ +++
SKM-1 TSA (+) + +
  Aza - (+) +
  Aza + TSA + + ++
U-937 TSA - + ++
  Aza - +++ +++
  Aza + TSA - +++ +++
  1. Induction of TSG expression by Aza (5 μM, 4 d) and TSA (2 μM, 1 d) when compared to untreated control cells: - < 2-fold, + ≥ 2-fold; ++ ≥ 10-fold, +++ ≥ 100-fold gene expression. Expression levels were determined by quantitative real-time PCR. Note that cell line SKM-1 shows hypomethylation and expression of IGSF4 and TIMP3 (Fig. 5). Experiments were performed at least twice. Brackets: effect variable.
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Molecular Cancer

ISSN: 1476-4598