Figure 11
From: Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models
Release of secreted cytotoxic factors diminishes considerably the size of soft-agarose colonies. (A) Pie chart showing percentage distribution of colonies of different mean diameters (colonies >20 μm in diameter were considered) in the soft-agaose plate containing untreated effector HepG2 cells and in the plate containing MMC treated effector HepG2 cells. (B) Photomicrographs of colonies at higher magnification showing diminished growth when MMC treated effector HepG2 cells were added in the center well of soft-agarose plate containing colonies of target cells.