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Figure 1 | Molecular Cancer

Figure 1

From: Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells

Figure 1

Pharmacological SDH inhibition increases histone methylation. (A). Immunoblot analysis of histone methylation in Hep3B, HT1080 and PC12 cells treated for 24 h with 500 μM 2-thenoyltrifluoroacetone (TTFA). In all cases lanes were loaded with 5 μg histone extract, and blots were analysed with the indicated antibodies. Histone H3 total expression was analysed as a loading control. (B) Densitometric analysis of three independent experiments. Fold increase was calculated as the ratio of methylated lysine to H3 control, between treatments.

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Molecular Cancer

ISSN: 1476-4598