Table 1 Well-differentiated and poorly differentiated HCC cell lines according to hepatocyte lineage, epithelial and mesenchymal markers, and in vitro motility and invasiveness assays
From: Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells
Cell Lines | Fetal Hepatocyte Marker | Epithelial & Hepatocyte Markers | Mesenchymal markers | Motility | Invasiveness | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | AFP | HNF4a | HNF1a | E-cadherin | vimentin | slug | Snail | Twist-1 | Twist-2 | Â | Â |
Well-differentiated | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
HepG2 | High | High | High | Low | (-) | Low | Low | Low | High | Low | Low [14] |
Huh7 | High | High | High | High | Low | (±) | Low | Low | (-) | Low | Low [14] |
Hep3B | High | High | High | High | Low | High | Low | (-) | (-) | Low | Low ([74] |
Hep40 | High | High | High | Low | High | (-) | High | High | Low | Low | n.t. |
Poorly differentiated | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
SNU398 | (-) | (-) | (-) | Low | High | Low | High | High | High | Low | n.t. |
SNU475 | (±) | (-) | (-) | (-) | High | High | High | High | Low | High | n.t. |
SNU449 | (-) | Low | (-) | (±) | High | Low | Low | High | High | High | n.t. |
SNU387 | (-) | (-) | (-) | (-) | Low | High | High | (-) | (±) | n.t. | n.t. |
FOCUS | (-) | (-) | (-) | Low | High | Low | (-) | (-) | Low | n.t. | n.t. |
Mahlavu | (-) | (-) | (-) | (±) | High | Low | (-) | High | Low | High | High [74] |
SNU182 | (-) | (-) | (±) | High | high | High | High | High | High | High | n.t. |