Figure 4
From: Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects
Opposite directions of TUSC2 targets modulation in HP2595/TUSC2 versus mesothelioma tumors. A. Graph shows fold change expression of 44 genes in mesotheliomas as opposed to MPM cells overexpressing TUSC2. Expression changes in mesothelioma are shown with red bars while in HP2595 cell line with blue bars. Only statistically significant modulation in mesothelioma as compared to normal peritoneum (p < 0.05) is shown. Gene names that correspond to numbers in the bottom are provided in Table 4. B. Representative plots for genes down-regulated in mesothelioma with high p-value, but upregulated by TUSC2. C. Representative plots for genes upregulated in mesothelioma with high p-value, but down regulated by TUSC2. Each plot shows Affymetrix IDs for each gene probes and respective p-value.