Figure 5
From: Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects
Molecular and biological properties of TUSC2. A. Similarity with the interferon regulatory factor IRF7 suggests DNA-binding property for TUSC2. N-terminus of TUSC2 shows ~40% identity with the IRF7 segment that contains a DNA-binding site (framed). Histogram shows positions conserved in the IRF protein family. The arginine residue (R) conserved throughout the IRF protein family is marked with asterisk. B. Different mechanisms of TUSC2 down-regulation in tumor and immune cells. Modulation of TUSC2 in tumor and host immune cellular compartments may contribute to tumor growth via blocking TUSC2 tumor suppressive or immune-regulatory properties.