Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects

Table 2 TUSC2 target genes grouped based on involvement in biological processes.

Chromatin structure	P value	Cell cycle	P value
nucleosome assembly	1.31E-06	cell growth and/or maintenance	0.0001
chromosome organization	1.97E-06	regulation of mitotic cell cycle	0.04
negative regulation of histone acetylation	0.007	cell cycle arrest	0.05
nucleosome disassembly	0.04	negative regulation of S phase	0.04
imprinting	0.04	negative regulation of cell proliferation	0.02
Cell differentiation	P value	Immune system related activities	P value
adipocyte differentiation	0.0008	complement activation	0.001
megakaryocyte differentiation	0.007	immune response	0.005
cell differentiation	0.01	antigen processing	0.007
Intra-and inter-cellular signaling	P value	innate immune response	0.02
cell-cell signaling	0.02	humoral immune response	0.04
cell surface receptor linked signal transduction	0.04	response to reactive oxygen species	0.01
regulation of G-pr. coupled receptor pr. signaling pathway	0.05	Synthesis and metabolism	P value
Other proceses	P value	glycolipid biosynthesis	0.02
viral assembly, maturation, and release	0.02	cAMP metabolism	0.02
lactation	0.04	valine metabolism	0.02
blood coagulation	0.04	regulation of hormone biosynthesis	0.03
transcription from Pol II promoter	0.04	nucleotide catabolism	0.03
Homeostasis and secretion	P value	proteoglycan metabolism	0.04
growth hormone secretion	0.02
calcium ion homeostasis	0.03
insulin secretion	0.04

Hypergeometric P-values define probability of involvement of potential TUSC2 in listed biological processes. Only statistically significant (p ≤ 0.05) associations are shown.

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