Figure 4
From: EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cells
A. Quantitative flow-cytometric representation of mitotic exit using two-color staining (MPM-2 and PI). Representative dot-plot shows that the mitotic population plummets at 36 hrs of EM011 treatment and there is a substantial increase in the 4N G2 population suggesting mitotic exit. B. Representative confocal immunofluorescence images of microtubules (green) and DNA (red) showing a multipolar mitotic cell (left panel) and a mitotically-exited G1-like multinucleate cell (right panel).