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Figure 5 | Molecular Cancer

Figure 5

From: Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

Figure 5

Activated Akt attenuates Aur-A inhibitory VX-680-induced apoptosis in TSCC cells. (a) Cells were incubated in serum-free media with indicated doses of VX-680 for 24 h, and subjected to Western blot analysis with pAkt (ser473), and Akt1 antibodies. (b) Myr-Akt1 or pUSE stable transfected cells were subjected to Western blot with pAkt and Akt1 antibodies, GAPDH was used as a control. (c) Myr-Akt1 or pUSE transfected cells were treated with VX-680 (5 nM or 10 nM) for 24 h. Cell survival rates were measured by MTT assay.

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Molecular Cancer

ISSN: 1476-4598