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Figure 2 | Molecular Cancer

Figure 2

From: Insulin-like growth factor binding protein-3 has dual effects on gastrointestinal stromal tumor cell viability and sensitivity to the anti-tumor effects of imatinib mesylate in vitro

Figure 2

Effect of IGFBP3 knockdown or neutralization on GIST882 cell viability. (A) GIST882 cells were treated with IGFBP3 blocking antibody (anti-IGFBP3) or control IgG (4 ug/mL) for 48 hours before cell viability was measured with the MTS assay. (B) GIST882 cells were transfected with siRNA duplexes specific to IGFBP3 (si-IGFBP3) or mismatch sequence (si-Control) and subsequently treated with imatinib (1 μM) for 48 hours. Cell viability was assessed with the MTS assay. Immunoblotting shows IGFBP3 expression after si-Control (si-C) or si-IGFBP3 (si-BP3) transfection.

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Molecular Cancer

ISSN: 1476-4598