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Figure 2 | Molecular Cancer

Figure 2

From: Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation

Figure 2

(A) Transient transfection of increasing concentrations of the EBNA1 expression plasmid pSG5-EBNA1 into parental Ad/AH cells inhibits NF-κB luciferase reporter activity in a dose-dependent manner. (B) Transient transfection of increasing concentrations of a dominant-negative EBNA1 (dnEBNA1) abrogates the ability of wild-type EBNA1 (wtEBNA1) to inhibit NF-κB luciferase activity in parental Ad/AH cells. Reporter assays were performed in biological and technical triplicate and error bars indicate SD (* = P < 0.05 relative to EBNA1-free controls).

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