Figure 8From: Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cellsMolecular mechanism of OPN-induced p70S6 kinase/mTOR regulated NF-κB/AP-1 mediated ICAM-1 expression in breast cancer cells. OPN induces αvβ3 integrin-mediated NF-κB/AP-1 dependent ICAM-1 expression. Overexpression of mTOR/p70S6 kinase suppresses OPN-induced ICAM-1 expression in breast cancer cells.Back to article page