Table 2 Genes coding for cell cycle regulatory molecules displaying altered expression in LP-1 derivatives (|FC|>3)
From: Cyclin K and cyclin D1b are oncogenic in myeloma cells
Gene | Protein | LP-1D1b vs. cl1 | LP-1K vs. cl1 |
|---|---|---|---|
SESN2 | Sestrin 2 | +3.36* | nm** |
DDIT3 | DNA-damage-inducible transcript 3 | +3.35 | nm |
CCNB1IP1 | Cyclin B1 interacting protein 1 | nm | +10.36 |
RASSF5 | Ras association (RalGDS/AP-6) domain family member 5 | nm | +4.79 |
CDNK1A | Cyclin-dependent kinase inhibitor 1A | nm | +4.30 |
CABLES1 | CDK5 and ABL enzyme substract 1 | nm | +3.30 |
MAD2L1 | MAD2 mitotic arrest deficient-like 1 | nm | -3.13 |
CCNB2 | Cyclin B2 | nm | -3.14 |
GAS2 | Growth-arrest specific 2 | nm | -3.22 |
MK167 | Antigen identified by monoclonal antibody Ki67 | nm | -3.37 |
PINX1 | PIN2-interacting protein 1 | nm | -3.57 |
CCNF | Cyclin F | nm | -3.65 |
CKS2 | CDC28 protein kinase regulatory subunit 2 | nm | -3.68 |
CHMP1A | Chromatin modifying protein 1A | nm | -3.87 |
CDK6 | Cyclin-dependent kinase 6 | nm | -4.14 |
CCNB1 | Cyclin B1 | nm | -5.23 |
CDKN3 | Cyclin-dependent kinase inhibitor 3 | nm | -6.53 |
CDKN2C | Cyclin-dependent kinase inhibitor 2C (p18) | nm | -8.18 |
CDKN2B | Cyclin-dependent kinase inhibitor 2B (p15) | -3.75 | -2.83 |