Cyclin K and cyclin D1b are oncogenic in myeloma cells

Table 3 Genes coding for signalization molecules displaying altered expression in LP-1 derivatives (|FC|>3)

Gene	Protein	LP-1D1b vs. cl1	LP-1K vs. cl1
FGFR3	Fibroblast growth factor receptor 3	+5.08*	nm**
AKT3	v-akt oncogene homolog 3	nm	-5.16
MET	HGFR, Met proto-oncogene	nm	-4.33
ITPKA	Inositol 1,4,5-triphosphate 3-kinase A	nm	-3.94
CD81	CD81 molecule	nm	+3.03
PIK3CG	Phosphoinositide 3-kinase gamma	nm	+3.20
DOK6	Docking protein 6	nm	+3.21
MAPK13	MAP kinase 13	nm	+3.25
ECOP	EGFR-overexpressed protein	nm	+3.39
PRKD2	Protein kinase D2	nm	+3.94
DUSP6	Dual specificity phosphatase 6	nm	+8.37
SKAP1	Src kinase associated phosphoprotein	nm	+9.28
SYK	Spleen tyrosine kinase	nm	+9.87
MAPK12	MAP kinase 12	nm	+10.10
BLK	B lymphoid tyrosine kinase	+2.39	+12.25

ISSN: 1476-4598