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Table 6 Genes coding for transcription factors displaying altered expression in LP-1 derivatives.

From: Cyclin K and cyclin D1b are oncogenic in myeloma cells

Gene

Protein

LP-1D1b vs. cl1

LP-1K vs. cl1

DDIT3

DNA-damage-inducible transcript 3

+3.34*

nm**

ATF3

Activating transcription factor 3

+2.27

nm

XBP1

X-box binding protein 1

+2.24

nm

IRF8

Interferon regulatory factor 8

+2.21

nm

RUNX1

Runt-related transcription factor 1

nm

+5.13

TCF4

Transcription factor 4

nm

+4.40

MITF

Microphtalmia-associated transcription factor

nm

+3.50

NOTCH2

Notch homolog 2

nm

+3.36

STAT5A

Signal transduction and transcription factor 5A

nm

+2.49

ETV6

Ets variant 6

nm

+2.32

MAF

v-maf musculoaponeurotic fibrosarcomaa oncogene homolog

nm

+2.25

MYC

v-myc myelocytomatosis viral oncogene homolog

nm

+2.08

ETS2

v-ets erythroblastosis virus E26 oncogene homolog

nm

+2.06

IRF4

Interferon regulated factor 4

nm

-2.25

RBPJ

Recombination signal binding protein for Ig kappa region

nm

-2.38

REL

v-rel reticuloendotheliosis viral onvogene homolog

nm

-3.63

RUNX2

Runt-related transcription factor related 2

nm

-4.80

MYBL2

v-myb myeloblastosis viral oncogene homolog-like 2

nm

-5.18

ATF4

Activating transcription factor 4

+2.75

+2.64

  1. *, ** see legend of table 2. Since minor alterations in the level of transcription factors could have dramatic effects on gene expression, we sorted genes with a |FC|>2. Only genes coding for transcription factors recognized in the literature as relevant for myeloma pathogenesis are indicated.