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Table 2 Smad mRNA expression in head and neck SCC and adjacent mucosa.

From: Smad2 and Smad6 as predictors of overall survival in oral squamous cell carcinoma patients

   All patients n = 65 Oral Cavity n = 40 Larynx n = 15 Oropharynx n = 8
Smad1 T 0.06 ± 0.06 0.06 ± 0.05 0.07 ± 0.06 0.06 ± 0.10
  M 0.05 ± 0.05 0.06 ± 0.05 0.05 ± 0.04 0.03 ± 0.05
   P = 0.017* P = 0.209 P = 0.256 P = 0.012
Smad2 T 0.15 ± 0.10 0.16 ± 0.10 0.17 ± 0.10 0.13 ± 0.10
  M 0.11 ± 0.09 0.11 ± 0.08 0.15 ± 0.10 0.08 ± 0.11
   P = 0.002* P = 0.020* P = 0.532 P = 0.036*
Smad3 T 0.15 ± 0.11 0.13 ± 0.08 0.18 ± 0.13 0.18 ± 0.16
  M 0.11 ± 0.09 0.10 ± 0.08 0.15 ± 0.12 0.06 ± 0.08
   P = 0.001* P = 0.028* P = 0.047* P = 0.017*
Smad4 T 0.13 ± 0.09 0.13 ± 0.08 0.15 ± 0.09 0.12 ± 0.12
  M 0.11 ± 0.08 0.12 ± 0.07 0.13 ± 0.08 0.09 ± 0.11
   P = 0.051* P = 0.202 P = 0.733 P = 0.017*
Smad5 T 0.10 ± 0.06 0.10 ± 0.05 0.12 ± 0.08 0.08 ± 0.07
  M 0.08 ± 0.06 0.08 ± 0.05 0.01 ± 0.07 0.04 ± 0.06
   P = 0.001* P = 0.006* P = 0.798 P = 0.036*
Smad6 T 0.03 ± 0.04 0.04 ± 0.04 0.03 ± 0.03 0.01 ± 0.01
  M 0.02 ± 0.02 0.03 ± 0.03 0.10 ± 0.01 0.01 ± 0.02
   P = 0.072* P = 0.132 P = 0.334 P = 0.833
Smad7 T 0.08 ± 0.06 0.09 ± 0.06 0.08 ± 0.06 0.04 ± 0.03
  M 0.04 ± 0.03 0.05 ± 0.03 0.03 ± 0.04 0.03 ± 0.03
   P<0.0001* P<0.0001* P = 0.002* P = 0.123
Smad8 T 0.02 ± 0.03 0.02 ± 0.03 0.02 ± 0.03 0.01 ± 0.01
  M 0.01 ± 0.02 0.01 ± 0.01 0.02 ± 0.03 0.01 ± 0.01
   P = 0.378 P = 0.389 P = 0.875 P = 0.496
  1. T: tumor, M: adjacent mucosa. Values are presented as median ± standard deviation, * significant differences by Wilcoxon test.