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Table 1 Selected genes differentially expressed in LNCaP prostate tumor cells after exposure to tasquinimod for 24 h.

From: Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors

Functional groups* Gene name Accession #† Gene‡ Locus In vitro In vivo
Angiogenesis/hypoxia      
CD36 antigen (TSP1 receptor) NM_001001547 CD36 948   +
Vascular endothelial growth factor NM_001025366 VEGF 7442   -
Thrombospondin 1 (THBS1, TSP1) NM_003246 THBS1 7057 + +**
Endothelial PAS domain protein 1 NM_001430 EPAS1 2034   +
Neuropilin 2 NM_003872 NRP2 8828   +
Stabilin1 NM_015136 STAB1 23166   +
Angiopoietin 2 NM_001147 ANGPT2 285 - -
Cadherin 13 NM_001257 CDH13 1012   +
Hypoxia-inducible protein 2 NM_013332 HIG2 29932   -
Cell cycle/differentiation/senescence/apoptosis      
Cyclin-depenent inhibitor kinase 1C NM_000076 CDKN1C 1028   -
Adrenomedullin NM_001124 ADM 133   -
Fibroblast growth factor NM_033136 FGF1 2246   +
Advanced Glycosylation Endproduct Recept NM_001136 AGER 177 -  
Leukocyte specific transcript protein 1 NM_007161 LST1 7941 +  
Forkhead box protein N4. NM_213596 FOXN4 121643   +
Jun D proto-oncogene; AP-1 complex NM_005354 JUND 3727   -
Invasion/migration/adhesion/metastasis      
Lysyloxidase preprotein NM_002317 LOX 4015 - -
Secreted phosphoprotein NM_00582 SPP1 6996 -  
Chemokine (C-X-C motif) receptor 4 NM_003467 CXCR4 7852   -
Spleen tyrosine kinase NM_003177 SYK 6850   +
Vimentin NM_003380 VIM 7431   +
CD44 antigen isoform a NM_000610 CD44 960   +
CD74 antigen NM_004355 CD74 972   +
Insulin-like growth factor binding prot 3 NM_000598 IGFBP3 3486   -
S100 calcium-binding protein A6 NM_014624 S100A6 6277   +
S100 calcium binding protein P NM_005980 S100P 6286   +
P8 protein (candidate of metastasis 1) NM_012385 NUPR1 26471   -
Matrix metalloproteinase 14 NM_004995 MMP14 4323   +
Latent transforming GFB-binding prot NM_032035 LTBP2 4053 +  
Insulin-like growth factor binding prot 7 NM_001553 IGFBP7 3490   +
Stress response/metabolism/DNA repair      
cytochrome P450, family 1, subfamily A NM_000499 CYP1A1 1543 + +
cytochrome P450, family 1, subfamily A NM_000761 CYP1A2 1544 +  
growth differentiation factor 15 (NAG1) NM_004864 GDF15 9518 +  
DNA-damage-ind. transcript 3 (GADD153) NM_004083 DDIT3 1649 + -
TCDD-inducible poly(ADP-ribose) polymerase NM_015508 TIPARP 25976 + +
Tumor protein p53 inducible nulear prot 2 NM_021202 TP53INP2 58476 +  
Inflammatory response      
Myeloperoxidase NM_000250 MPO 4353 -  
Interleukin 8 receptor beta NM_001557 IL8RB 3579   -
Interleukin 12 alpha chain NM_000882 IL12A 3592 -  
Serpin peptidase inhibitor 1 NM_001085 SERPINA3 12 -  
  1. * Functional classification by gene annotation enrichment analysis, gene clustering analysis and pathway mapping based on Gene Ontology data in DAVID Bioinformation database, †Genebank accession number.
  2. ‡Presented genes were significantly up (+) or down (-) regulated (FDR < 10%) in ≥3 out of 4 biol replicates.
  3. ** Expressed in 2 out of 4 replicates
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