Molecular Cancer

Table 1 Selected genes differentially expressed in LNCaP prostate tumor cells after exposure to tasquinimod for 24 h.

From: Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors

*Functional groups** Gene name	Accession #^†	Gene^‡	Locus	*In vitro*	*In vivo*
*Angiogenesis/hypoxia*
CD36 antigen (TSP1 receptor)	NM_001001547	CD36	948		+
Vascular endothelial growth factor	NM_001025366	VEGF	7442		-
Thrombospondin 1 (THBS1, TSP1)	NM_003246	THBS1	7057	+	+**
Endothelial PAS domain protein 1	NM_001430	EPAS1	2034		+
Neuropilin 2	NM_003872	NRP2	8828		+
Stabilin1	NM_015136	STAB1	23166		+
Angiopoietin 2	NM_001147	ANGPT2	285	-	-
Cadherin 13	NM_001257	CDH13	1012		+
Hypoxia-inducible protein 2	NM_013332	HIG2	29932		-
*Cell cycle/differentiation/senescence/apoptosis*
Cyclin-depenent inhibitor kinase 1C	NM_000076	CDKN1C	1028		-
Adrenomedullin	NM_001124	ADM	133		-
Fibroblast growth factor	NM_033136	FGF1	2246		+
Advanced Glycosylation Endproduct Recept	NM_001136	AGER	177	-
Leukocyte specific transcript protein 1	NM_007161	LST1	7941	+
Forkhead box protein N4.	NM_213596	FOXN4	121643		+
Jun D proto-oncogene; AP-1 complex	NM_005354	JUND	3727		-
*Invasion/migration/adhesion/metastasis*
Lysyloxidase preprotein	NM_002317	LOX	4015	-	-
Secreted phosphoprotein	NM_00582	SPP1	6996	-
Chemokine (C-X-C motif) receptor 4	NM_003467	CXCR4	7852		-
Spleen tyrosine kinase	NM_003177	SYK	6850		+
Vimentin	NM_003380	VIM	7431		+
CD44 antigen isoform a	NM_000610	CD44	960		+
CD74 antigen	NM_004355	CD74	972		+
Insulin-like growth factor binding prot 3	NM_000598	IGFBP3	3486		-
S100 calcium-binding protein A6	NM_014624	S100A6	6277		+
S100 calcium binding protein P	NM_005980	S100P	6286		+
P8 protein (candidate of metastasis 1)	NM_012385	NUPR1	26471		-
Matrix metalloproteinase 14	NM_004995	MMP14	4323		+
Latent transforming GFB-binding prot	NM_032035	LTBP2	4053	+
Insulin-like growth factor binding prot 7	NM_001553	IGFBP7	3490		+
*Stress response/metabolism/DNA repair*
cytochrome P450, family 1, subfamily A	NM_000499	CYP1A1	1543	+	+
cytochrome P450, family 1, subfamily A	NM_000761	CYP1A2	1544	+
growth differentiation factor 15 (NAG1)	NM_004864	GDF15	9518	+
DNA-damage-ind. transcript 3 (GADD153)	NM_004083	DDIT3	1649	+	-
TCDD-inducible poly(ADP-ribose) polymerase	NM_015508	TIPARP	25976	+	+
Tumor protein p53 inducible nulear prot 2	NM_021202	TP53INP2	58476	+
*Inflammatory response*
Myeloperoxidase	NM_000250	MPO	4353	-
Interleukin 8 receptor beta	NM_001557	IL8RB	3579		-
Interleukin 12 alpha chain	NM_000882	IL12A	3592	-
Serpin peptidase inhibitor 1	NM_001085	SERPINA3	12	-

* Functional classification by gene annotation enrichment analysis, gene clustering analysis and pathway mapping based on Gene Ontology data in DAVID Bioinformation database, ^†Genebank accession number.
^‡Presented genes were significantly up (+) or down (-) regulated (FDR < 10%) in ≥3 out of 4 biol replicates.
** Expressed in 2 out of 4 replicates

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ISSN: 1476-4598

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